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Vaccines via pillor nasal spray
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"Would the form of the vaccine influence your take-up of it? The Oxford team are looking at vaccine tablet or nasal spray versions. "
Not for healthy adults with no other issues. No one likes a needle but you do it anyway. I think this should just be the quickest way to create theme
For people with fears, disabilities and children- definitely   |
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I'm phobic, but no.
I heard a suggestion - just a hint of an idea, mind (sort of, this is possibly the case) - that nasal vaccines might be more effective than needles. But unless or until that's proven so and is the type on the market, I'll take what I'm given. |
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"I'm phobic, but no.
I heard a suggestion - just a hint of an idea, mind (sort of, this is possibly the case) - that nasal vaccines might be more effective than needles. But unless or until that's proven so and is the type on the market, I'll take what I'm given."
There's the concept that a nasal spray could deliver the vaccine to the point of likely first entry in to the body, where infection can build - the vaccine could do the reverse, potentially building strong immunity starting at the same place. It's over simplistic I'm sure, as the whole body can create a substantial, comprehensive immune response.
I can see that our global shortage of supplies like syringes could be overcome via alternative delivery vehicles and styles. And also that some people could be more inclined to take a tablet, rather than get a needle. It may be quicker to deliver via these alternatives, potentially cheaper and overcoming stringent storage requirements for liquids.
The biggest ease, if it was a new pandemic, could be the very high volume delivery to more people, enabling a more rapid reduction in deaths/infections and potentially reaching herd immunity. For poorer countries, with minimal health care facilities and networks, tablets may be a more appropriate solution. That said, vaccination under supervision does help to ensure that people get the treatments that they need. |
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"I'm phobic, but no.
I heard a suggestion - just a hint of an idea, mind (sort of, this is possibly the case) - that nasal vaccines might be more effective than needles. But unless or until that's proven so and is the type on the market, I'll take what I'm given.
There's the concept that a nasal spray could deliver the vaccine to the point of likely first entry in to the body, where infection can build - the vaccine could do the reverse, potentially building strong immunity starting at the same place. It's over simplistic I'm sure, as the whole body can create a substantial, comprehensive immune response.
I can see that our global shortage of supplies like syringes could be overcome via alternative delivery vehicles and styles. And also that some people could be more inclined to take a tablet, rather than get a needle. It may be quicker to deliver via these alternatives, potentially cheaper and overcoming stringent storage requirements for liquids.
The biggest ease, if it was a new pandemic, could be the very high volume delivery to more people, enabling a more rapid reduction in deaths/infections and potentially reaching herd immunity. For poorer countries, with minimal health care facilities and networks, tablets may be a more appropriate solution. That said, vaccination under supervision does help to ensure that people get the treatments that they need. "
It certainly has a number of plus points. I hope it's investigated, for Covid and otherwise.
Needles terrify me but I'll suck it up. |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely"
Depends on the degree of the needle phobia.
As a child I had to learn not to instinctively attack the person with the needle. If I hadn't settled down (I'm still scared) and I didn't think getting vaccinated was personally beneficial, then a spray might tip the balance for me. (I'll get the jab as soon as I'm offered) |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely"
There's a big difference between hating needles and being genuinely phobic.
Our son has refused treatment rather than have an injection. |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely
There's a big difference between hating needles and being genuinely phobic.
Our son has refused treatment rather than have an injection. "
I'm probably low level phobic. "Swing you must not hit the nurse. Swing you must not hit the nurse". It's a mantra. It took years of training  |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely
There's a big difference between hating needles and being genuinely phobic.
Our son has refused treatment rather than have an injection.
I'm probably low level phobic. "Swing you must not hit the nurse. Swing you must not hit the nurse". It's a mantra. It took years of training "
Our son passes out. At that point consent can't be given. I know why he's phobic. He was very ill when he was 6 weeks old and had to have blood tests, it was obviously terrifying for him |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely
There's a big difference between hating needles and being genuinely phobic.
Our son has refused treatment rather than have an injection.
I'm probably low level phobic. "Swing you must not hit the nurse. Swing you must not hit the nurse". It's a mantra. It took years of training
Our son passes out. At that point consent can't be given. I know why he's phobic. He was very ill when he was 6 weeks old and had to have blood tests, it was obviously terrifying for him"
I get it. Well, not literally, but I empathise. I get queasy and faint, and struggle to resist lashing out. I usually bite myself. (But obviously given my thyroid condition, blood tests are part of my life)
I'd much prefer a nasal vaccine, but I *can* and do handle needles. It'd be better to give less fear/phobia inducing treatment where possible. |
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"I hate needles but cannot undersand why it would make people more likely to have vaccine as long as the results are the same that is what matters surely
There's a big difference between hating needles and being genuinely phobic.
Our son has refused treatment rather than have an injection.
I'm probably low level phobic. "Swing you must not hit the nurse. Swing you must not hit the nurse". It's a mantra. It took years of training
Our son passes out. At that point consent can't be given. I know why he's phobic. He was very ill when he was 6 weeks old and had to have blood tests, it was obviously terrifying for him
I get it. Well, not literally, but I empathise. I get queasy and faint, and struggle to resist lashing out. I usually bite myself. (But obviously given my thyroid condition, blood tests are part of my life)
I'd much prefer a nasal vaccine, but I *can* and do handle needles. It'd be better to give less fear/phobia inducing treatment where possible."
Yes it would if it were possible.
We're looking in to ways to help him overcome his phobia. |
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By (user no longer on site)
over a year ago
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There’s quite a few alternative technologies out there, which have come and gone, like transdermal injections. For one reason or another they haven’t taken off. |
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Nasal spray vaccines already exist. The children's flu vaccine is in this form. It's a live virus vaccine so very different to the Covid vaccines. The issue would be establishing a mechanism to get the mRNA or viral vector to be taken up in sufficient quantities by the nasal epithelial cells, to provoke a sufficient immune response. The fact is that jabbing into a large muscle gets the vaccine material into the bloodstream rapidly and thus rapidly to cells. This efficiency cannot be mirrored by a spray up the nose, so formulations and all sorts of other things need to change. |
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"Birmingham university have already developed one. It could be in the shops for summer. For some reason no one is talking about it! "
The Birmingham uni development is potentially great, as an immediate protective agent. It's not 1 of the vaccines that will get the body to produce immunity, as far as I can recall, like the Pfizer, Oxford or Modrrna vaccines etc. |
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By (user no longer on site)
over a year ago
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"There’s quite a few alternative technologies out there, which have come and gone, like transdermal injections. For one reason or another they haven’t taken off. "
Swansea University are currently working on a "smart patch"
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The problem with new technology is getting people to invest in rolling it out, even if it works. If it's cheaper and easier to keep jabbing people with hypodermics, why spend tons on an alternative that might not, at least at first, be any more effective? That's why it's taken since 1989 to get an mRNA vaccine to market, for example. Finally the world saw the need to speculate, but in the past, despite the technology being there, no investor fancied backing that unknown horse. |
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By (user no longer on site)
over a year ago
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I have no problem with needles or vaccinations. But tablets could be a good idea for some, particularly in getting the rest of the world protected where tablets would be much easier to distribute than the vaccine. |
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"I have no problem with needles or vaccinations. But tablets could be a good idea for some, particularly in getting the rest of the world protected where tablets would be much easier to distribute than the vaccine."
A tablet vaccine is pretty hard to conceive. It'd have to survive the highly acidic pH of the stomach and I'd imagine this is rather challenging for biological material which denatures at such pH. Also the issue of storage for stability etc. |
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By (user no longer on site)
over a year ago
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"I have no problem with needles or vaccinations. But tablets could be a good idea for some, particularly in getting the rest of the world protected where tablets would be much easier to distribute than the vaccine.
A tablet vaccine is pretty hard to conceive. It'd have to survive the highly acidic pH of the stomach and I'd imagine this is rather challenging for biological material which denatures at such pH. Also the issue of storage for stability etc. "
I don't know about the technical side of it. Just thinking of distribution, particularly to third world countries. |
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By (user no longer on site)
over a year ago
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I'm sure children under 5 get given a flu vaccine in a maisel spray. I'm pretty sure all though I could be wrong even if they have a disability or needle phobia cant have it. |
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"There’s quite a few alternative technologies out there, which have come and gone, like transdermal injections. For one reason or another they haven’t taken off. Swansea University are currently working on a "smart patch""
The nose filters are also being re worked and coating nasal sprays similar to hay-fever sprays |
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Vaccines in pill form have been under development for some years, with flu and others amongst them. There's a covid vaccine pill under trial at present and others in development. Production, transport and patient delivery are lower cost and easier. Perfect for 3rd world countries, with sparse medical facilities or impossible low temperature storages options of liquid vaccines.
A major problem this year has been production and availability of syringes and needles, which needs are eliminated with pills. |
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"Vaccines in pill form have been under development for some years, with flu and others amongst them. There's a covid vaccine pill under trial at present and others in development. Production, transport and patient delivery are lower cost and easier. Perfect for 3rd world countries, with sparse medical facilities or impossible low temperature storages options of liquid vaccines.
A major problem this year has been production and availability of syringes and needles, which needs are eliminated with pills. "
Yes, I heard a comment about whether a needle shortage might mean a nasal vaccine is needed. |
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