At long last some actual proper evidence as opposed to the hydroxychloroquine/Trump make it up as you go along stuff
This is how medicine has evolved to where we are today- study, trials, evidence etc - it’s the way humans and science progresses |
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By (user no longer on site)
over a year ago
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Yeah, but I’ve got inside information that says that the company who distributes dexamethasone worldwide is owned by Bill Gates. Makes you think?
Actually that’s a lie! But someone will say it.
In fact it’s the first BBC latest news update for months that filled me with real hope. Long may it continue |
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It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient |
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By (user no longer on site)
over a year ago
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"Lets not go down the route of slating other users for what they say...lets just be hopeful that this is a breakthrough"
Point taken, apologies
It’s brilliant news though |
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient "
I’m sure it helped 20% of patients on oxygen. |
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient "
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen |
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen "
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Dexamethazone is a common and well used steroid.
It was (maybe still, used I don't know, I retired 4 years ago) given to women who were at risk of premature birth in order to 'mature' the babys lungs ready for birth.
I can't remember just how it worked either, although I used to a short while ago!
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By *eroy1000Man
over a year ago
milton keynes |
An excellent step forward and much needed. I hear it was UK trials and research that discovered it but that may be just the government boasting and why not. I hear its a very old drug too so very cheap |
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"Yeah, but I’ve got inside information that says that the company who distributes dexamethasone worldwide is owned by Bill Gates. Makes you think?
Actually that’s a lie! But someone will say it.
In fact it’s the first BBC latest news update for months that filled me with real hope. Long may it continue "
Lol I was just about to call you a bad name  |
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"Great to see we are finally starting to develop a working arsenal against this thing. Still no silver bullet but a huge step forward. "
Quite right, best way to look at it really is another weapon in the arsenal |
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"Great to see we are finally starting to develop a working arsenal against this thing. Still no silver bullet but a huge step forward.
Quite right, best way to look at it really is another weapon in the arsenal"
The experimental blood clot drug from Australia is going through trials now so fingers crossed for that one to succeed |
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By (user no longer on site)
over a year ago
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen "
Presumably if you are mild enough to not need oxygen then you not gonna die anyway? |
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By (user no longer on site)
over a year ago
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"An excellent step forward and much needed. I hear it was UK trials and research that discovered it but that may be just the government boasting and why not. I hear its a very old drug too so very cheap"
Fiver a pop and available without licence world wide as it dates back to 1957. On hospital pharmacy shelves already.... |
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen
Presumably if you are mild enough to not need oxygen then you not gonna die anyway?"
Yep. I think the poster was just stating the research findings |
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By *eeleyWoman
over a year ago
Dudley |
"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen
Presumably if you are mild enough to not need oxygen then you not gonna die anyway?"
I think it's excellent news, most people will never get to the stage where they need ventilators, it's fantastic there is some treatment for the people with the worst symptoms. |
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"It's working for those who needed ventilation, trial said the drug had no impact on those who didn't need ventilation but took it. Hopefully a blood clot treatment will be achieved to run along with it then the recovery time will be easier on the patient
Greatest benefit for those needing ventilation not the only benefit
20% reduction in mortality for those needing oxygen but not ventilation
No benefit for those mild enough not to need oxygen
Presumably if you are mild enough to not need oxygen then you not gonna die anyway?"
yes - the mortality for those patients who either don't need admission or do but never need oxygen is much much lower than those who do
so the fact this works on that group that have the highest risk of death makes it all the more useful |
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It really cheered me up to hear this.  . The world needs good news. It should save a high number of people from death and presumably organ damage due to cytokine storm attack.
Great news from the UK team. The fact that it's low cost should also be great for poorer countries. |
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Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
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"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
"
Seems a small increase in chances when viewed on its own, but when you figure it could have saved 5000 lives if used since the start of the outbreak, then you've got to be happy with that.
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"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
"
1/3 of those on ventilators and 1/5 of those on oxygen isn't worth bothering about ? |
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"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
"
You literally are the only one not excited etc about it.
Think what it could lead to, less deaths being the huge one and I'm sure people all over the world with loved ones on ventilators will welcome the even slightly higher chance they'll survive given this treatment also if the government knew about the drugs effects on covid its estimated it could have saved 5000 lives.
So yes in summery it is exciting news |
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By *asIsaCouple
over a year ago
harrow |
"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
"
Really? So 30 out of 100 on ventilation could survive and that's a 'small' increase? Sounds very positive news to me |
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By (user no longer on site)
over a year ago
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"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
"
It's the first bit of good news the world has had in a treatment against Corona. So yeah I think its bloody good news as it's a step in the right direction.
I'm just surprised that on the virus room this has got very little posts on it. |
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"Am I the only one not excited and optimistic about this?
Yes anything that reduces the mortality rate is a good thing but the level of excitement over what is actually only a small increase in the chances of surviving seems a bit premature.
It's the first bit of good news the world has had in a treatment against Corona. So yeah I think its bloody good news as it's a step in the right direction.
I'm just surprised that on the virus room this has got very little posts on it."
I know I thought the same.
Everyone jumps on a negative thread. A positive one and it has just 17 replies when I looked for it this morning. |
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By *abioMan
over a year ago
Newcastle and Gateshead |
it would make sense that some of the different steroids would help as they are anti-inflamatories...
the other thing is that it only helps the most seriously ill as covid seems to infect the lungs and inflames them!
as someone else says... anything that will help in the arsenal! |
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation.  "
No that’s wrong I’m afraid
Asthma is an inflammatory disorder so steroid help
In infections outside asthma etc it’s uncommon for steroids to be used |
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation.
No that’s wrong I’m afraid
Asthma is an inflammatory disorder so steroid help
In infections outside asthma etc it’s uncommon for steroids to be used"
Yeah doesn't it sometimes multiply the problems if given for some conditions? |
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation.
No that’s wrong I’m afraid
Asthma is an inflammatory disorder so steroid help
In infections outside asthma etc it’s uncommon for steroids to be used
Yeah doesn't it sometimes multiply the problems if given for some conditions? "
all im saying is i would have thought they would have looked into it before now after all there was research into what good bleach based products would be.
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As a general principle - if it’s an infection alone steroids suppressing your immune system doesn’t help and can help
If it’s the inflammatory response of your own body to an infection that’s doing more damage than the virus is eg what happens with covid, or with conditions like asthma, steroids suppressing the immune system does help
So it’s a case of picking which conditions they work for and which you should avoid them in |
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation.
No that’s wrong I’m afraid
Asthma is an inflammatory disorder so steroid help
In infections outside asthma etc it’s uncommon for steroids to be used
Yeah doesn't it sometimes multiply the problems if given for some conditions? all im saying is i would have thought they would have looked into it before now after all there was research into what good bleach based products would be.
"
The trial was started fairly early in the covid timeline in the UK, this is as quick as you ever get answers from research |
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation.
No that’s wrong I’m afraid
Asthma is an inflammatory disorder so steroid help
In infections outside asthma etc it’s uncommon for steroids to be used
Yeah doesn't it sometimes multiply the problems if given for some conditions? all im saying is i would have thought they would have looked into it before now after all there was research into what good bleach based products would be.
The trial was started fairly early in the covid timeline in the UK, this is as quick as you ever get answers from research "
Correct, firstly we need to recruit a suitable number of patients to the study to collect enough data to show that the drug will be both effective and safe, that’s a basic principal of GCP.
Secondly, as this is a pandemic and requires a a more time critical response you are actually seeing the fast tracking of treatments. This means they acquire NICE approval for the given indication much quicker than a normal study.
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By (user no longer on site)
over a year ago
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"As an asthmatic sufferer i would have thought steroids would have been the first thing they would be giving to people suffering from a lung condition which causes oxygen starvation. "
I assume it was put forward to being researched, by doctors who have used this to treat the excessive inflammatory response due to covid (ie those on O2 and those on ventilators) and had some success.
Like you and I know, steroids are used for respiratory issues. I am just surprised it has taken this long for the results. |
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By (user no longer on site)
over a year ago
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"This is the scientific rationale for the use of dexamethasone in the study
https://www.recoverytrial.net/files/professional-downloads/recovery-intervention-sheet-dexamethasone-v2-0.pdf"
Thanks.
Interesting effect of potential hyperglycaemia. |
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By *asyukMan
over a year ago
West London |
Good news.
It's what happens when the professionals are allowed to get on with it without interference from politicians or shareholders.
The benefit of it being unglamorous.
Well done to the teams still grinding through all of the other existing drugs to assess their efficacy win or lose  |
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"Well I guess all those doctors wasted so much time when they could have got all the advice they needed here 
It would help if this sneering would stop, it doesn't add anything to a debate and just sends a thread the wrong way
People can have a different view than you without being attacked this way"
As a medic myself I agree.
I feel some people may comment with good intentions but limited knowledge and don’t need to be met with disparaging remarks. |
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